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4.4 Targeting mitochondria autophagy to increase tumor immunity Mitochondrial autophagy, as a core mechanism regulating mitochondrial homeostasis, exerts bidirectional effects in tumor immunity by influencing immune cell function, tumor microenvironment metabolism, and innate immune pathways: It can maintain effector function by clearing damaged mitochondria from immune cells and enhance immune responses by activating the STING pathway

415 The potential mechanism underlying this synergy is that D-pen upregulates the copper transport proteins hCtr1 and ATP7A, which share a transport system with platinum, 416 thereby increasing intracellular platinum levels

Cao Z, Qin H, Huang Y, Zhao Y, Chen Z, Hu J, et al

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